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Electronic cigarettes (or e-cigs) are refillable and reusable devices that have a battery and cartridge filled with e-juicea liquid mixture of propylene glycol (PG), vegetable glycerin (VG) and flavorings

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The participants will be identified only by a unique participant ID number on all study documents and any electronic database, with the exception of the CRF, where participant initials may be added

The 133 current cigarette users, including 58 e-cigarette users (43.6%), 33 combined users (24.8%), and 42 conventional cigarette users (31.6%) (Figure 1), received the self-reporting online questionnaires sent to them at baseline, 90, 180, 270, and 360 days to collect information on exposure, outcome, and confounders

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