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When someone smokes, vapes, or uses tobacco, the nicotine in tobacco normally binds to certain receptors in the persons brain in order to give feelings of pleasure, or at the very least relief from nicotine withdrawal.(2) Varenicline binds to these nicotine brain receptors and which makes the person have fewer cravings.(2) If the person smokes, vapes or uses tobacco on top of taking varenicline, the varenicline will block the nicotine in the tobacco products from attaching to those receptors