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Many of these diseases do not manifest clinically until many years after the first cigarette has been smoked

This study was supported by grants from the National Cancer Institute of the National Institutes of Health.

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Moreover, menthol itself is a toxicant, and prior in vitro evidence suggests that menthol-flavored E-liquids have a lower pH than other E-liquids and induce high levels of cell death in a range of model systems 49,50 , in line with their greater cytotoxic potency relative to UEL preparations in this study