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8 Healthy Ageing Research Healthy ageing research has identified progressive declines in collagen production, extracellular matrix integrity and regenerative capacity as characteristic features of ageing tissues

Lysyl oxidase (LOX)mediated collagen cross-linking further increases ECM rigidity, which in turn activates integrinFAKYAP/TAZ and Wnt/-catenin signaling pathways, and promotes epithelialmesenchymal transition (EMT) and fibrogenesis (126)

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