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More than 17,000 adults Overweight or obesity (body mass index 27 or higher) Established cardiovascular disease (such as prior heart attack, stroke, or peripheral artery disease) No diabetes This was mostly a secondary prevention populationpeople who already had cardiovascular disease

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Major clinical trials including SUSTAIN and STEP programs established semaglutide's 15-22% weight loss effectiveness and metabolic benefits across doses of 0.5mg to 2.4mg weekly

Glucocorticoid and Adrenergic Receptor Distribution Across Human Organs and Tissues: A Map for Stress Transduction