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In line with this, in the SEC analysis of the mixture between aged A and the A-anticalin, we found a slight shift to a lower elution volume (in line with larger size by ~2.7 kDa) as well as a broadening of the peak compared to the anticalin protein alone (Fig

Together, these findings suggest that the aberrant astrocytic GABA in PTSD is possibly driven by enhanced synthesis via MAOB and reduced degradation via ABAT in reactive astrocytes, contributing to the excessive inhibitory tone observed in PTSD