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As we explained in the CY 2025 PFS final rule (see 89 FR 98157), the health equity benchmark adjustment (HEBA), was designed to encourage new participation from ACOs serving medically complex, high-cost populations that are receiving lower regional adjustments or lower prior savings adjustments or receiving neither adjustment

Role of Pyruvate Kinase in Regulation of Insulin Secretion Within pancreatic -cells, pyruvate kinase (PK) is localized to the plasma membrane closely associated with the KATP channel

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doi: 10.1016/j.euroneuro.2023.12.010 2 OwenMJSawaAMortensenPB